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BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thoughtMutations in the BRCA1 gene that are either inherited ... And of the 263 screened for germline ATM variants, 7(3%) tested positive. Among the 124 undergoing germline testing based on high risk ...
The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.
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