The investigators found that the FGFR3 variant associated with achondroplasia, the most common form of short-limbed dwarfism, does increase with the father's age. Another variant, this one ...

28 If both parents have achondroplasia, then testing the pregnancy for homozygosity or compound heterozygosity for mutations in FGFR3 is readily available, because 97% of patients with ...

In achondroplasia patients, the temporal lobe—an area of the cortex—forms incorrectly. These malformations are linked to a ...

Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been shown to drive oncogenesis in a subset of patients with multiple myeloma. However, epithelial cancers — such as bladder ...

Tyra Biosciences' TYRA-300 shows promise as an FGFR3 inhibitor with fewer side effects, but mixed market reactions spotlight ...

Achondroplasia is a rare genetic disorder of bone growth that causes short-limbed dwarfism. It occurs due to mutations in a single gene called the FGFR3.