B) This model, based on x-ray crystallography data, shows how the amino acid chain of a TLR folds up to form ... enabling interaction and assembly of adaptor proteins (MYD88, TRAM, TRIF, and ...

The identification of mammalian TLR innate sensors was an outgrowth ... Although TREM-mediated signaling is known to occur via the adaptor protein DAP12, how individual TREM proteins are ...

From this library, peptides were identified that specifically bind to key TLR adapter proteins like MyD88TIR and MALTIR.

Now, the researchers have uncovered a surprising twist in finding that these TLR-like LRR proteins serve a structural role, ...