The landmark discovery of the BCL-2 gene and its function marked the inhibition of apoptotic cell death as a crucial mechanism driving cancer development. This new review brings together some of ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated ... BAD is not ubiquitously expressed 10, and mice that have had their BAD gene deleted are viable (S.

Venetoclax is a B cell lymphoma 2 (BCL-2) inhibitor that has shown promising ... The team identified a special six-gene pattern that can help predict which patients are more likely to respond ...

The MYC gene is a regulatory and proto-oncogenic gene ... and change in the mRNA levels of BCL-2/Bax, PTEN, and CDK4 as a consequence of MYC downregulation. Moreover, the researchers analyzed ...

John Seymour, MBBS, FRACP, PhD, explains why BCL-2 was considered an undruggable target for so long and what led to the development of effective BCL-2 inhibitors.