Predictive biomarkers of immunotherapy response are critical for clinical practice. In this study, baseline plasma sCD27 was ...
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University of Birmingham identifies target to reduce GVHD riskOur lab tests showed that blocking the interaction between CD70 and its partner molecule, CD27, reduced the aggressive behaviour of these T-cells. “This suggests that interrupting this CD70-CD27 ...
Research by Oflazoglu and colleagues now suggests that CD27–CD70 blockade could be a promising therapeutic strategy for autoimmune and autoinflammatory disorders. In addition, because the ...
Engineered to target CD70-positive cancers, ADI-270 uses a third-generation CAR, leveraging CD27 as the binding component. The drug includes a dominant negative form of the transforming growth ...
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