A minimum of 3 positive founders will be delivered. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF ...

This innovation could significantly enhance our understanding of gene functions in complex organisms ... induces guide RNA (gRNA) in cells, which then binds to Cas9, leading to the editing ...

It can deliver its payloads, including genome editing compounds such as CRISPR-Cas9, gRNA and DNA ... an adverse immune response remains a complex hurdle in the pharmaceutical industry ...

We provide transgene expression in mammalian cell lines using lentiviral and retroviral transduction and gene knockout and knockin using CRISPR/Cas9 technologies ... and assess the functionality of ...