Substantial evidence indicates that this is mediated by the rapid activation of cyclin B–Cdk1, which is the core component of M-phase-promoting factor (MPF). This kinase was initially identified ...

Cyclin-dependent kinases (CDKs ... The current nomenclature for CDK proteins includes 11 classical CDKs (CDK1–11), two newly proposed family members (CDK12 and 13) and additional proteins ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.