NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

"Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes, COX-1 and COX-2, which are used by the body to make signaling molecules called ...

Important considerations when investigating NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous substrate arachidonic acid, the mechanism of ...

Cyclo-oygenase (COX) was the key enzyme that these drugs inhibited. Later, two forms of COX were identified, and it was possible to selectively inhibit each of them. For a general summary overview ...

Their findings suggest potential interplay between cyclooxygenase enzyme, or COX, and indoleamine dioxygenases, or IDOs, during inflammation.

When investigating NSAID inhibition of COX in vitro some important considerations are the source of the enzyme, the Michaelis constant (K m) of the endogenous substrate arachidonic acid ...