RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

for example—is translated using self-folding RNA alone. First, a DNA sequence is designed in a computer-assisted process. It ...

use RNA to guide them to specific sites on DNA. TIGR systems can be reprogrammed to target any DNA sequence of interest, and they have distinct functional modules that can act on the targeted DNA.

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

Researchers have identified an ancient RNA-guided system that can target DNA, potentially expanding the genome-editing toolbox.

Imagine a world where we could predict the behavior of life just by analyzing a sequence of letters. This is not science ...