Nature3mon
Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape
The original idea was logical. FasL expressed on tissues would engage the Fas receptor expressed on the surfaces of immune cells, causing them to undergo programmed cell death ().The idea that ...
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Therapeutic approach to treat virus-induced lung failure for severe COVID-19 shows promise in clinical trial
A new clinical study shows that an inhibitor of Fas ligand (FasL), also called CD95 ligand (CD95L), led to a faster recovery of COVID-19 patients and reduced mortality. On average, it took eight ...
Nature1mon
Fas counter-attack–the best form of tumor defense?
FasL-negative, subcutaneous AK-5 tumors showed ... O'Sullivan, G.C., Collins, J.K. & Shanahan, F. The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.
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Dissecting the Cellular Pathways Behind CAR T Cell Therapy
The Fas and FasL pathway is based on trimerization of the Fas receptor by the Fas ligand, which subsequently activates ...