The chief clinical features of FFI include a progressive and ferocious insomnia, waking "sleep," hallucinations, autonomic disturbances suggestive of sympathetic overdrive (tachycardia ...

As fatal familial insomnia progresses, patients completely stop sleeping and enter a coma-like state that results in death within months. Children need to inherit only one copy of the mutant PRNP ...

Can’t sleep? It could be worse, you could be dead. And sometimes, not being able to sleep could kill you. That’s what happens in cases of fatal familial insomnia. FFI is a degenerative ...

The genetic history of sisters Carolyn Schear (at right) and Cheryl Dinges puts them at risk for fatal familial insomnia, a deadly inability to sleep. Schear learned she doesn’t carry the gene.

Imagine a genetic condition that not only steals your sleep but ultimately your life - that’s fatal familial insomnia (FFI) in a nutshell. This rare disease - also in the piron family - affects ...

Symptoms of fatal familial insomnia (FFI) can only be slowed through treatment temporarily, according to Cleveland Clinic. FFI affects an estimated one to two people per million every year ...

[25] Sleep deprivation may result from endogenous factors (such as aging or chronic insomnia) or exogenous prevention of sleep state (such as deliberate waking). The longest period of voluntary ...