Because the AIDS-causing pathogen HIV integrates its genome into that of infected host ... mostly the viral reverse transcriptase and protease. Unfortunately, HIV is highly variable and therefore ...

But unlike the many, more common antiviral drugs that can be used to fight against viruses such as flus, protease inhibitors can also be used to help combat HIV (human immunodeficiency virus).

Efforts to elucidate the HIV life cycle, aided by the genome sequence of the virus, revealed that a virally encoded aspartyl protease was crucial in viral replication. Specific design of protease ...

HIV drug susceptibility tests can evaluate either the genotype or phenotype of the predominant viral quasispecies. The HIV genotype refers to the actual DNA sequence of the virus; the phenotype ...

After reverse transcription, the proviral DNA is integrated into cellular genome and will synthesize ... The following year a second protease inhibitor to treat HIV became available.

The HIV capsid's unique strategy doesn't stop there. Unlike other transporters, it completely encapsulates its cargo, camouflaging the viral genome from the watchful eyes of anti-viral sensors in ...

and then transfers this processed strand into the host cell’s genome. Integrase inhibitors stop the virus from inserting itself into the DNA of human cells. Protease inhibitors (PIs) block the ...