Hosted on MSN29d
Researchers identify Lhx2 as key gene in hepatic stellate cells regulating liver regeneration and fibrosis
using Lrat-cre (HSC-specific cre) mice and AAV8-DIO-mLhx2 virus, they overexpressed Lhx2 specifically in HSCs, confirming that Lhx2 promotes liver regeneration and repair after acute injury while ...
Fierce Biotech6d
Researchers identify potential MASH target after gene disruption triggers liver symptoms in mice
The result suggests that the protein made by the gene, known as Nwd1, and other molecules it interacts with could be ...
EurekAlert!2y
c-kit IRES-Cre Mice Allow for Molecular Layer Interneurons Targeting in Mature Mice (IMAGE)
The cerebella from c-kit IRES-Cre mice injected with Cre-reporter virus at PND (pups shortly after birth) 0 or PND 64. Tissue was prepared from animals 27 and 14 days after injection ...
Nanoparticle immune therapy shows potential in mice to treat and prevent spread of pancreatic cancer to liver
Pancreatic cancer that spreads to the liver is especially difficult to treat because the liver naturally suppresses immune ...
Hosted on MSN2mon
‘Ticking time bombs’ in your liver: How damaged cells escape cancer safeguards
or you progress to frequently fatal liver cancer.” The research team used mouse models and human tissue specimens to demonstrate that diets high in fat and sugar – which can induce MASH ...