HHMI researchers solve a longstanding mystery about the origin of new cells in the liver. Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to ...

The aging and failure of cells that occurs when the liver is damaged can spread to other organs, suggests a new study in mice ...

The aging and failure of cells that occurs when the liver is damaged can spread to other organs, suggests a new study in mice ...

A more recent approach is transplantation of mature liver cells, known as hepatocytes. “The problem is obtaining sufficient quantities of fully functioning hepatocytes,” says Ochiya.

The research team set their sights on the three genes. One, FOXM1, is present in liver cells called hepatocytes and can trigger liver cancer, inflammation and fibrosis if it becomes overactive.

The most common type is hepatocellular carcinoma, which begins in the main type of liver cell (hepatocyte). Other types of liver cancer, like intrahepatic cholangiocarcinoma and hepatoblastoma, are ...

Mesenchymal stem cells (MSCs) once looked likely to avoid such attacks. However, recent studies have shown that some MSCs are more immunogenic than others. Liver-derived MSCs, such as Promethera ...

To grow their space-age liver organoids, Chang and her team use "induced pluripotent stem cells," which are adult cells reprogrammed to be stem cells that can give rise to different kinds of tissue.

Their findings, entitled “Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch,” were published in Cell on October 29, 2024. Why it matters ...