We have developed a series of targeted mice expressing frontotemporal-dementia-causing mutations in the humanized MAPT gene to investigate the earliest stages of tauopathy." Tau ...

With both diseases, genetics are thought to play a central role. This includes a known mutation affecting the MAPT gene which regulates tau protein production. While many people with Pick's ...

Encoded Therapeutics Inc., a clinical-stage biotechnology company developing genetic medicines for severe central nervous system (CNS) disorders, today announced the results of preclinical studies ...