Few mouse tumor models, however, are conducted in the orthotopic site. Even if orthotopic implantation studies are done, the therapy is typically initiated in mice harboring a small tumor volume ...

Scientists explore how daily glucocorticoid signaling influences glioblastoma growth and synchronizes its circadian rhythms ...

including in vivo models such as orthotopic xenograft models and patient-derived xenografts, as well as in vitro molecular biology tools like CRISPR for gene knockout, knockdown, and overexpression in ...

Data demonstrate dose dependent survival advantage with AUTX-703 in primary patient-derived orthotopic AML model IND submissions ... by identifying and inhibiting the oncogenic cell states of cancer, ...