One important problem that may arise during PARP inhibitor treatment is the development of resistance. Even BRCA-deficient mouse tumors were reported to acquire resistance to PARP inhibitors.

Scientists have worked out a way of predicting how long a prostate cancer patient will continue to respond to the PARP ...

Reseachers from WEHI (Melbourne, Australia) have found a new way to predict a subset of patients who are likely to become ...

PARP inhibitor Number of completed or ongoing ... Simplified schematic of homologous recombination mechanism. Upon double strand break induction BRCA1 promotes 5′ to 3′ end resection whereas ...

Big players have been carving out a niche in the small but thriving field of poly(ADP-ribose) polymerase (PARP) inhibitors, as long-awaited data roll out that validate the experimental approach.

Other PARP inhibitors have validated the mechanism of action in cancers of the ovary, breast, prostate and pancreas. IDX-1197 has several key advantages over those commercially available PARP ...