In the search for anticancer drugs, a promising area involves the design of small-molecule inhibitors of growth factors active in malignancies. PDGF and its receptors are implicated in ...

BAY43-9006 (Sorafenib) Small-molecule inhibitor BRAF, EGFR, c-kit, PDGFR, VEGFR-2 and 3 Phase II-III (in combination with chemotherapy) TKI258 (CHIR-258) Small-molecule inhibitor VEGFR, ...

Investigations of small-molecule inhibitors of p38 mitogen-activated ... including the platelet-derived growth factor receptor (PDGFR), c-kit, and ABL-related kinases; imatinib also potently ...

Seralutinib, an inhaled PDGFR, CSF1R, and c-KIT inhibitor, is central to the company's development efforts in this therapeutic area. While the company is currently operating at a loss ...

Addition of the PDGFR/KIT/ABL kinase inhibitor imatinib to the combination eliminated any residual downstream signalling and dramatically inhibited cell viability. Importantly — as lack of ...