The technological demand for bioconjugate chemistry is fueled by the exponential growth of pharma and biopharma. The protein targeting chemistry comprises varying aspects, including precision protein ...

Once attached, the E3 ligase tags the unwanted protein with a molecular "trash signal," telling the cell ... the potential for toxic side effects. "Targeting specific mutant proteins, such as ...

Nucleus-encoded mitochondrial precursor proteins possess targeting signals that are recognized by receptors on the mitochondrial surface. The targeting signals then direct the precursors to their ...

The human immune system has a formidable arsenal of defenses to detect and eliminate threats. One of its most powerful guardians is the complement ...

They then used CRISPR-Cas9 to eliminate the target gene and create EGFR knockouts. A western blot of protein extracted from these knockout cells showed that there was no longer any signal for a ...

This ensures that when multiple signals are present ... Further validation steps demonstrated that input proteins correctly reconstituted their target proteases. By altering perceptein component ...

Scientists have a new target to prevent cold sores after University of Virginia School of Medicine researchers discovered an unexpected way the herpes virus re-activates in the body.