Comparing human and mouse Purkinje cells to better understand human brain complexity
Purkinje cells (PCs) are a type of neuron cell found in the cerebellum. They are some of the largest and most intricate and ...
mskcc.org6y
Cerebellum development and regeneration
Unlike other brain regions, the cerebellum has multiple progenitor zones (Leto, 2015; Joyner & Bayin, 2022)(Fig. 1C-E). The ventricular zone gives rise to all the GABAergic (inhibitory) cells ...
Frontiers14h
The diversity of the plasticitome
The plasticity of synaptic connections is critical to the functioning of local circuits as it is thought to underlie information processing and storage in the brain. Traditionally, synaptic plasticity ...
The Scientist11d
Sleep Disruptions and Impaired Muscle Control in Ataxia May Share a Culprit
Dysfunctional neurons in the cerebellum, a brain region that controls motor functions, reduced REM sleep in mice.
Scientists find a determining mechanism for synapse formation in the cerebellum
The work published in the journal Cell Reports describes the molecular ... which is expressed by cerebellar Purkinje neurons, ...
Capsida Biotherapeutics to Present New Preclinical Data for Potential Best-in-Class Friedreich's Ataxia Next-Generation Gene Therapy
Capsida Biotherapeutics ("Capsida") today announced new preclinical data for CAP-004, a potential best-in-class systemically ...
University of Texas at San Antonio4y
The Santamaria Computational Neuroscience Laboratory
In this case, we combine electrophysiology, multi-photon imaging, and biophysical modeling to understand the computational function of changes in intrinsic excitability in cerebellar Purkinje cells.