Scientists have made a major discovery about ADAR1—a protein that controls RNA-induced immune responses—paving ...

A research team led by Rice University's Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...

Editing RNA isn’t all that different from DNA base-editing techniques, which typically use Cas9 or other enzymes attached to a CRISPR guide RNA to replace one nucleotide with another. In the case of ...

Over the years, scientists have explored alternatives to Cas9, such as Cas12a for more precise multigene editing, a type III CRISPR for RNA editing, and a Cas13 loaded with multiple guide RNAs for ...

ADAR1 converts adenosine to inosine in double-stranded RNA, a process essential for preventing unwarranted immune responses, yet the molecular basis of this editing had remained unclear. Through ...

By studying this amazing structure, how did scientists learn about RNA editing? The first tools developed for the study of cells and tissues were optical microscopes. These microscopes use visible ...

ProQR Therapeutics is advancing its Axiomer ADAR-mediated RNA editing pipeline, aiming to file a Clinical Trial Application for its lead program AX-0810, targeting NTCP for cholestatic diseases ...

These systems, which the researchers call TIGR (Tandem Interspaced Guide RNA) systems ... had adapted bacterial CRISPR systems into gene-editing tools that have transformed modern biology.

A research team led by Rice University’s Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...

The Tas protein uses an RNA guide to recognize a specific target ... uncover ancient systems with potential to expand the genome editing toolbox. These systems, which the researchers call TIGR ...

ADAR1 converts adenosine to inosine in double-stranded RNA, a process essential for preventing unwarranted immune responses, yet the molecular basis of this editing had remained unclear.