Analysis of the 5′ ends of the cDNA by 454 pyrosequencing yielded approximately 250,000 expressed sequence tags (ESTs) from one run of sequencing. The data also showed marked heterogeneity of ...

A group of researchers led by Professor Claudia Höbartner at the University of Würburg (JMU) has now uncovered the three-dimensional structure of a very special ribozyme: SAMURI. This is an RNA ...

The team’s research, published this week in the Proceedings of the National Academy of Sciences, describes a ribozyme that ...

and the researchers set about further optimizing the ribozyme. After a series of modifications to the Sm1 sequence, the team developed N79, a clone that triggered highly efficient cleavage and ...