The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But where does translation take place within a cell?

TriLink BioTechnologies® and the International Vaccine Institute Sign a Memorandum of Understanding to Support the ...

One study outlined the key areas that need to be overcome: the stability, immunogenicity, translation efficiency, and delivery of mRNA therapies. On the last point, there are already attempts to ...

However, the therapeutic effectiveness is limited by the poor translation uptake of naked mRNA. To circumvent this challenge, researchers from VIB, VUB, Ghent University, and eTheRNA ...

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Follow-up studies confirmed that this nucleoside modification improved mRNA translation capabilities and stability. In the last decade, a series of studies highlighted the powerful potential of ...

How does a COVID-19 mRNA vaccine work? COVID vaccines are now available. Some of the COVID-19 vaccines are mRNA vaccines, but what does this mean? mRNA vaccines are different from traditional ...

When developing mRNA therapeutics, capping technology plays a crucial role in determining the stability, translation efficiency and immunogenicity of synthetic mRNAs. Advancements in ...