t (15;17) (q24;q21) PML/RARA - atlasgeneticsoncology.org
Mar 1, 2016 · t (15;17) (q24;21) is associated conbsistently with AML M3. This chromosomal abnormality first appeared to be confined to the characteristic or morphologically typical M3 …
Acute Promyelocytic Leukemia with T(15;17): Frequency of …
Nov 16, 2008 · Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by t (15;17) (q22;q21), a balanced reciprocal translocation …
Acute promyelocytic leukemia - Wikipedia
The disease is characterized by a t (15;17) chromosomal translocation [4] involving the retinoic acid receptor alpha (RARA) gene and is distinguished from other forms of AML by its …
t (15;17) in acute promyelocytc leukemia - PMC
The diagnostic translocation t (15;17) between chromosomes 15 and 17, which is responsible for the distinctive biology of APML, was definitively established in a seminal publication by …
The t (15;17) translocation in acute promyelocytic leukemia
Acute promyelocytic leukemia is characterized by a specific t (15;17) chromosomal translocation and a particular sensitivity to retinoic acid. The translocation fuses the PML gene to the …
Hidden abnormalities and novel classification of t(15;17) acute ...
Feb 19, 2009 · Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t (15;17), resulting in the formation of the PML …
Cryptic t(15;17) acute promyelocytic leukemia with a karyotype of …
We report a cryptic t (15;17) APL patient with a complex karyotype, including add (11) (p15) and t (13;20) (q12;q11.2), who achieved CR with polychemotherapy combined with ATRA and ATO …
Understanding Acute Promyelocytic Leukemia - What's Special About t(15;17…
May 1, 2006 · Almost always, a unique translocation [t (15;17)] leads to the production of a fusion oncoprotein made up of the first part of PML, an unrelated protein, and the last part of RARα …
Chromosomal translocation t(15;17) in human acute …
Aug 23, 1991 · A unique mRNA produced in leukemic cells from a t (15; 17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor α (RARα) …
Molecular analysis of the t (15;17) translocation in acute ...
Oct 1, 1992 · This chapter will focus on the characterization of the molecular events resulting from the t (15;17) translocation, namely the fusion of the retinoic acid receptor a gene (RARA) to …