Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. [5] [6]

The ALK gene provides instructions for making a protein called ALK receptor tyrosine kinase, which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and related health conditions.

Dec 24, 2024 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma . Among its related pathways are crizotinib-resistant ALK mutants and GPCR Pathway .

This gene change is called an ALK fusion or ALK rearrangement and can cause cancer. When this fusion happens, a patient is said to be ALK-positive. The most common gene that ALK fuses with is called EML4.

Jan 27, 2021 · The anaplastic lymphoma kinase (ALK) mutation is one of those gene changes. Knowing whether your cancer is ALK positive can help your doctor figure out which treatments will work best...

A gene that makes a protein that is involved in cell growth. Mutated (changed) forms of the ALK gene and protein have been found in some types of cancer, including neuroblastoma, non-small cell lung cancer, and anaplastic large cell lymphoma. These changes may increase the growth of …

Jun 8, 2021 · ALK non-small cell lung cancer happens when the anaplastic lymphoma kinase (ALK) gene mutates. Early diagnosis and treatment give people the best possible outlook.

Mar 7, 2025 · Genetic alterations of ALK in cancer include chromosomal rearrangements, activating point mutations or ALK protein overexpression that typically supports oncogenesis by inducing constitutive...

ALK stands for anaplastic lymphoma kinase. It is a gene that provides instructions for making a protein involved in cell growth and communication. ALK is normally found in specific types of cells in the nervous system, where it helps regulate how these cells grow and function.

The ALK gene encodes anaplastic lymphoma kinase. Fusions of the ALK gene with a variety of 5’ (upstream) partner genes upregulate ALK’s kinase activity and contribute to tumorigenesis. ALK gene fusions have been reported in diverse tumor types.