Anabasine is a nicotinic acetylcholine receptor agonist. In high doses, it produces a depolarizing block of nerve transmission, which can cause symptoms similar to those of nicotine poisoning and, ultimately, death by asystole. [3] In larger amounts it is thought to be teratogenic in swine. [4]

Concentrations of anabasine and anatabine were used to validate abstinence in smokeless tobacco users who used nicotine gum as part of the therapy. Correlations of alkaloid concentration with self-reported tobacco use before treatment ranged from fair to poor.

Anabasine is a nicotine analog that is an alkaloid found in tree tobacco (Nicotiana glauca) and is comprised of a pyridine substituted by a piperidin-2-yl group at position 3.

Anabasine sulfate was a widely used botanical insecticide in the former Soviet Union until the 1970s. Anabasine (Figure 3.2), a close structural relative of nicotine, was isolated from the toxic Asian plant Anabasis aphylla (Chenopodiaceae) by Orechoff and Menschikoff in 1931.

Anabasine is a partial agonist at α4β2 nAChRs with lower affinity than nicotine, but it has a greater affinity than nicotine for the α7 subtype, at which it is a full agonist and hypothesized to exert most of its effects in vivo (Daly, 2005; Kem et al., 1997).

Aug 8, 2022 · Smoking ≥20 CPD was associated with 3.6× higher anabasine GM and 4.8× higher anatabine GM compared with smoking <10 CPD. Compared with non-daily smoking, daily smoking was associated with higher GMs for urinary anabasine (1.41 ng/mL vs. 6.28 ng/mL) and anatabine (1.62 ng/mL vs. 9.24 ng/mL).

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Anabasine is a nicotinic acetylcholine receptor agonist. In high doses, it produces a depolarizing block of nerve transmission, which can cause symptoms similar to those of nicotine poisoning and, ultimately, death by asystole. In larger amounts it is thought to be teratogenic in swine.

Anabasine is the well-known alkaloid contained in the herb Anabasis aphylla L. [3, 4]. Anabasine in small doses excites the central nervous system, enhances breathing, and increases blood pressure.

Anabasine is a clear liquid with a boiling point of 281°C. Its freezing point is 9°C. The density of anabasine is 1.048 g/cm 3 at 20°C. The alkaloid is miscible with water and most organic solvents. Anabasine from A. aphylla is levorotatory , but the alkaloid obtained for practical purposes from the American N. glauca is mostly racemic.