Sep 1, 2008 · Early B-cell development is characterized by the ordered rearrangement of Ig H and L chain loci, and Ig proteins themselves play an active role in regulating B-cell development. 31 Pivotal to understanding how early B-cell development is regulated was the discovery of surrogate L chains (SLCs).

Since the identification of B cells in 1965 (Cooper et al. 1965), three has been tremendous progress in our understanding of B cell development, maturation and function. A number of B cell subpopulations, including B-1, B-2 and regulatory B cells, have been identified.

The maturation of B cells is a tightly regulated process that ensures the development of a diverse B cell repertoire capable of recognizing a wide range of antigens while avoiding harmful self-reactivity.

Oct 13, 2024 · B-cell development originates from hematopoietic stem cells and involves several stages of early differentiation, progressing through maturation, antigen interaction, and antibody synthesis.

Germinal Center B (GCB) vs Activated B cell (ABC) DLBCL are distinguished by Gene expression profiling (GEP) or IHC.

After production in the BM, immature surface IgM+ B cells migrate to the spleen where they differentiate through distinct transitional B cell stages termed T1 and T2, before differentiating into long-lived mature follicular (FO) or marginal zone (MZ) B cells.

Apr 23, 2020 · The major stages of B cell development in the BM include the HSC, the multipotent progenitor (MPP), the common lymphoid progenitor (CLP), and then the progenitor B cell (pro-B cell), the precursor B cell (pre-B cell) and the immature B cell.

Sep 26, 2023 · These cells form part of the adaptive immune response by producing antibodies and presenting antigens to T cells. Once activated, they can mature into plasma cells or memory B lymphocytes. This article covers B cell development and subtypes. B and T lymphocytes arise from common lymphoid progenitor cells within the bone marrow.

Stage 4: Mature B-Cell: Only those immature B cells that pass the selection test, ensuring they don’t react against self-antigens, graduate to become mature B cells. These mature B cells are ready to leave the bone marrow and enter the bloodstream, …

To become a B cell, it has to develop into an immature B-cell in the bone marrow and then complete its maturation into an antibody secreting B cell, called a plasma cell, in the lymph nodes and spleen. To become a T cell, it has to migrate to the thymus and become a thymocyte, where it completes its development into a mature T cell.