Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. These lines are only visible in those with a mosaic [1][2][3] skin condition or in chimeras where different cell lines contain different genes. [4]

Blaschko lines or the lines of Blaschko are thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus. This concept was first described by the German dermatologist Alfred Blaschko in 1901 at the 7th Congress of German Dermatological Society.

Apr 7, 2023 · These benign skin lesions, called epidermal nevi, follow the lines of Blaschko and make them visible. Image credit: Bygum et al, BMC Medical Genetics 2011 (CC BY 2.0); cropped. It might not...

Jun 14, 2023 · Mutations involving color-producing cells can lead to pigmentary mosaicism presenting as streaks and swirls following Blaschko lines. Type 1a and 1b in the image below are the most typically seen varieties, while the others are less common.

Blaschko's lines represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. They differ from dermatomes, and appear as single or multiple lines, whorls (swirls) and wave-like shapes in the skin.

What is the relationship between Blaschko lines and cutaneous mosaicism? Cutaneous lesions following Blaschko lines are a manifestation of cutaneous mosaicism. They represent lines of division of the two cell lines within the embryonic skin tissue.

The lines of Blaschko are a pattern of lines on the skin that represent the developmental growth pattern during epidermal cell migration. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures.

First described by Dr. Alfred Blaschko in 1901, the lines of Blaschko were identified through his observations of over 140 patients with linear skin lesions. These lesions followed specific patterns, which led Dr. Blaschko to diagram the distribution of these lines across the human body.

Jan 1, 2016 · Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. These lines are invisible under normal conditions. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns.

Sep 1, 2008 · In 1901, the German dermatologist Alfred Blaschko described a system of cutaneous lines that represented the typical pattern that linear nevi appeared to follow. 1 Because many skin disorders that followed these lines were present at birth, Blaschko suspected that they had an embryonic origin.