The role of CXCL family members in different diseases
Jul 1, 2023 · CXCL5, known as epithelial activating neutrophil protein, plays a role in immune system and inflammation. CXCL6, also known as granulocyte chemotactic protein 2, is a chemoattractant for ...
CXCL5 Gene - GeneCards | CXCL5 Protein | CXCL5 Antibody
Oct 1, 2024 · CXCL5 (C-X-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include Pulmonary Sarcoidosis and Extrinsic Allergic Alveolitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling.
CXCL5: A coachman to drive cancer progression - PubMed
Aug 1, 2022 · C-X-C motif chemokine ligand 5 (CXCL5) is a member of the chemokine family binding CXCR2 (C-X-C Motif Chemokine Receptor 2), a G-protein coupled receptor. Accumulated evidence has shown that dysregulated CXCL5 participates in tumor metastasis and angiogenesis in human malignant tumors.
CXCL5: A coachman to drive cancer progression - Frontiers
Jul 8, 2022 · C‐X‐C motif chemokine ligand 5 (CXCL5) is a member of the chemokine family binding CXCR2 (C-X-C Motif Chemokine Receptor 2), a G-protein coupled receptor. Accumulated evidence has shown that dysregulated CXCL5 participates in tumor metastasis and angiogenesis in human malignant tumors.
Mechanistic role of CXCL5 in cardiovascular disease, diabetes …
Oct 1, 2023 · Chemokine CXC motif ligand 5 (CXCL5) is one of the inducible chemokines that may be involved in various inflammatory diseases. Given the bidirectional promiscuity characteristics of the chemokine system, the mechanistic roles of CXCL5 should be further explored in each specific disease.
The CXCL5/CXCR2 axis is sufficient to promote breast cancer ... - Nature
Sep 27, 2019 · This study suggests that CXCL5 and CXCR2 inhibitors may have efficacy in treating metastatic bone tumors dependent on the CXCL5/CXCR2 axis.
CXCL5 promotes gastric cancer metastasis by inducing epithelial ...
Jul 6, 2020 · We explored the mechanism for CXCL5-mediated metastasis and found that CXCL5 enhanced GC cell migration and invasion by activating ERK signaling pathway and inducing EMT.
CXCL5 C-X-C motif chemokine ligand 5 [ (human)] - National …
CXCL5 gene polymorphisms are functional and associated with variable blood pressure in cardiovascular disease-free individuals. CXCL5 promotes HCC cell proliferation, invasion, and intratumoral neutrophil infiltration. Preoperative serum CXCL5 could serve as a novel predictive marker for prognosis determination of colorectal cancer patients.
Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 …
Further infection studies using CXCL5 −/− mice confirmed that the CXCL5 protein was likely responsible for neutrophil recruitment to the infected lungs. These results indicate that pulmonary infection with SARS-CoV-2 induced massive neutrophil infiltration in the lungs of infected mice at the early innate immune stage and that CXCL5 is a ...
Solution Structure of CXCL5 — A Novel Chemokine and Adipokine ...
Apr 2, 2014 · CXCL5 elicits its functions by binding CXCR2 but the outcome is highly context dependent. In the lung, CXCL5 mediates neutrophil trafficking in response to microbial infection by activating both G-protein and arrestin mediated signaling pathways , .
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