Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle [2] until mitosis, where they fall abruptly due to degradation of …

Dec 24, 2024 · CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230).

May 13, 2010 · In this review we discuss currently known targets of Cdk1 in the budding yeast S. cerevisiae and highlight the role of Cdk1 in several crucial processes including maintenance of genome stability. In eukaryotic cells, the cell cycle is controlled by …

Jan 21, 2016 · CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and is conserved across all eukaryotes. Here we report the crystal structures of complexes of CDK1-Cks1 and CDK1-cyclin B-Cks2.

bTrCP在调控CDK1活性方面发挥重要作用。通过诱导CDC25A和EMI1的降解防止CDK1的过早激活，通过介导G2期WEE1的降解促进CDK1的激活。同样，在G2期，cyclin F关闭E2F的活性，阻止复制组蛋白的合成，参与中心体复制的调控，并介导CDH1的降解。

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]

here we describe how CDK1 alone or in complex with cyclin B1 controls crucial ‘unconventional’ biological functions through the phosphorylation of a highly connected signalling network (Fig....

Mar 14, 2025 · Cyclin-dependent kinase 1 (CDK1) is a critical enzyme driving cell cycle progression, particularly the transition from G2 to M phase. Targeting CDK1 with inhibitors has gained attention for its potential in cancer therapy, as …

Feb 26, 2025 · Phosphorylation of condensins by cyclin B-CDK1 promotes chromosome condensation by altering structure and activity of condensins complex, allowing them to properly package and organize genetic material before cell division.

In this study, we use a biosensor specific for cyclin B1–Cdk1 activity to show that activating cyclin B1–Cdk1 immediately triggers its rapid accumulation in the nucleus through a 40-fold increase in nuclear import that remains dependent on Cdk1 activity until NEBD.