Inhibition of the CDK2 and Cyclin A complex leads to ... - Nature
May 20, 2022 · Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase …
Here we show that depletion of Cyclin A or inhibition of Cdk2 during late S/early G2 phase maintains the G2 phase arrest by reducing Cdh1 transcript and protein levels, thereby …
Inhibition of the CDK2 and Cyclin A complex leads to autophagic ...
May 20, 2022 · Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2
Here we show that depletion of Cyclin A or inhibition of Cdk2 during late S/early G2 phase maintains the G2 phase arrest by reducing Cdh1 transcript and protein levels, thereby …
Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 ...
In this study, we investigated the role of cyclin A/Cdk2 complexes in the initiation of mitosis in human cells. The abundance and activity of these complexes rises strongly during S and G2 …
Regulation of Cyclin A-Cdk2 by SCF Component Skp1 and F-Box …
In this study, we investigated the potential regulation of cyclin A-Cdk2 activity by Skp1 and Skp2. We found that Skp2 can inhibit the kinase activity of cyclin A-Cdk2 in vitro, both by direct …
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates …
Apr 11, 2019 · Here the authors use an integrated approach and show that Cdk2/cyclin A-bound p27 samples lowly-populated conformations that dynamically anticipate the sequential steps of …
Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events
Mar 31, 2008 · We have used siRNA to knock down cyclin A2, the major cyclin A isoform in somatic cells, and a small molecule inhibitor specific for cdk2, to examine the role of the G 2 …
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA …
E2F-1 forms a heterodimer with DP-1 and binds to several cell cycle regulatory proteins, including the retinoblastoma family (RB, p107, p130) and cyclin A/CDK2 complexes. We have analyzed …
Modulating the interaction between CDK2 and cyclin A
Jan 1, 2014 · Compound 2 has been discovered that both disrupt cyclin dependent 2 (CDK2) interaction with its cyclin A subunit and act as ATP competitive inhibitors. Multiple cellular …