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    https://en.wikipedia.org › wiki › Desmosterol

    Desmosterol - Wikipedia

    Desmosterol (Cholesta-5,24-dien-3β-ol) is a lipid present in the membrane of phytoplankton and an intermediate product in cholesterol synthesis in mammal cells. Structurally, desmosterol has a similar backbone to cholesterol, with the exception of an additional double bond in the structure of desmosterol. The … See more

    Background

    Desmosterol is classified as a cholestadienol, a subgroup of a wider known group of sterols, which naturally occur in eukaryotes. The presence of desmosterol in … See more

    Biological occurrence image
    Biosynthesis

    There are two major pathways for cholesterol biosynthesis, being the Kandutsch-Russell and Bloch pathways. The Bloch pathway, … See more

    Measurement techniques image
    Measurement techniques

    Desmosterol has seen to be identified most commonly through chemical constants, ozonolysis, infrared spectroscopy, NMR, and mass spectrometry techniques. … See more

    Overview image
    Use as a Biomarker image
    Biological occurrence

    Desmosterol has been largely found within a large population of marine invertebrates. Major sources include barnacles, red algae See more

    Biosynthesis image
    Preservation

    Desmosterol has been seen to be present in marine sponges as a biomarker. However, bacterial symbiont sterol 24-C-methyltransferases is … See more

    Use as a Biomarker

    As a biomarker, desmosterol is important for the Chaetoceros calcitrans and R. setigera and N. closterium diatoms as well as See more

    See also

    • Cholesterol
    • Triparanol See more

    From Wikipedia
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    Background
    Biological occurrence
    Biosynthesis
    Preservation
    Use as a Biomarker
    Measurement techniques
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  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Alzheimer’s Disease: Brain Desmosterol Levels - PMC

  3. ScienceDirect
    https://www.sciencedirect.com › ... › desmosterol

    Desmosterol - an overview | ScienceDirect Topics

    Tags:
    Desmosterol
    Cholesterol
  4. Studies of Desmosterol
    National Center for Biotechnology Information
    Alzheimer’s Disease: Brain Desmosterol Levels
    Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer’s disease (AD) because of the report that the activity of the gene coding for th...
    Author: Thomas Wisni…
    Published: 2013/01/01
    DOI: 10.3233/JAD-201…
    National Center for Biotechnology Information
    Desmosterol: A natural product derived from macroalgae modulates inflammatory response and oxidative stress pathways in intestinal epithelial cells
    The serum level of cholesterol and its biosynthetic intermediates are critical indicators to access metabolism-related disorders in humans and animals. However, the molecular actions of these intermediates on gene functions and regulation remained elusive. Here, we show that desmosterol (DES) is the...
    Author: Huan Qu, Qiuf…
    Published: 2022
    Publication: Front Imm…
    PubMed
    Alzheimer's disease: brain desmosterol levels
    Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of the gene coding for th...
    Author: Thomas Wisni…
    Published: 2013
    Keywords: National In…
    National Center for Biotechnology Information
    Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses
    Inflammation and macrophage foam cells are characteristic features of atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to inflammation and LXR-dependent response pathways are poorly understood. To investigate this relationship, we utilized lipidomic and transcriptomic met...
    Author: Nathanael J. S…
    Published: 2012/09/09
    DOI: 10.1016/j.cell.201…
    PubMed
    Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
    Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophages in response to inflammatory stimuli or lipid overloading, respectively. However, the participation of these sterols in regulating macrophage functions in the physiological contex...
    Author: Xinbo Zhang
    Published: 2021/11/23
    Keywords: atheroscler…
    ScienceDirect
    Review Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis
    3β-Hydroxysterol Δ24-reductase (DHCR24) catalyzes the conversion of desmosterol to cholesterol. This ultimate step of cholesterol biosynthesis appears to be remarkable in its diverse functions and the number of diseases it is implicated in from vascular disease to Hepatitis C virus (HCV) infection t...
    Published: 2013/10/01
    Cited By: 0
    Keywords: ACTH adre…
    National Center for Biotechnology Information
    Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
    Previous work has shown that foamy macrophages accumulate desmosterol, a cholesterol biosynthetic intermediate. However, the participation of desmosterol in regulating the functions of cholesterol-laden macrophages in the physiological context of atherosclerosis has remained elusive. In this work, w...
    Author: Xinbo Zhang, …
    Published: 2021/11/11
    Publication: Proc Natl …
  5. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Desmosterol: A natural product derived from macroalgae …

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    Desmosterol Immune
    Front Immunol. 2022; 13: 1101643.
    Published:2022
  6. PubChem
    https://pubchem.ncbi.nlm.nih.gov › compou…

    Desmosterol | C27H44O | CID 439577 - PubChem

    Oct 14, 2021 · Desmosterol is a cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol. It has a role as a human …

    Tags:
    Desmosterol Levels
    Desmosterol Immune
    Desmosterol Too High
  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Alzheimer's disease: brain desmosterol levels - PubMed

    Tags:
    Desmosterol Levels
    Publish Year:2013
    Alzheimer's disease
  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Malformation syndromes caused by disorders of cholesterol …

    Tags:
    Desmosterol Levels
    Cholesterol
  9. People also ask
    Is desmosterol a lipid?
    ?) Desmosterol (Cholesta-5,24-dien-3β-ol) is a lipid present in the membrane of phytoplankton and an intermediate product in cholesterol synthesis in mammal cells. Structurally, desmosterol has a similar backbone to cholesterol, with the exception of an additional double bond in the structure of desmosterol.

    Desmosterol - Wikipedia

    en.wikipedia.org
    How does desmosterol affect sterol synthesis?
    Desmosterol accumulation, like cholesterol, signals sterol overload in the cell. It can serve as a ligand for LXR, promoting cholesterol efflux , and like cholesterol, is similarly sensed by Scap to inhibit SREBP-2 cleavage, and shut down cholesterol synthesis and uptake .

    Desmosterol - an overview | ScienceDirect Topics

    sciencedirect.com
    How is desmosterol similar to cholesterol?
    The similarity can be seen biologically through the synthesis of cholesterol in the human body, as desmosterol is the immediate precursor to cholesterol in the Bloch pathway. Desmosterol is accumulated in desmosterolosis and undergoes reduction with the catalyst 24-dehydrocholesterol reductase to form cholesterol.

    Desmosterol - Wikipedia

    en.wikipedia.org
    Does desmosterol reduce de novo cholesterol synthesis?
    In addition to activating ABCA1-mediated cholesterol efflux, desmosterol decreases de novo cholesterol synthesis by inhibiting the sterol response element-binding protein-2 and HMG-CoA reductase (Yang et al., 2006). Eser J. Zerenturk, ... Andrew J. Brown, in Progress in Lipid Research, 2013

    Desmosterol - an overview | ScienceDirect Topics

    sciencedirect.com
    Is desmosterol a cholesterol precursor?
    Desmosterol is a cholesterol precursor, differing from cholesterol by only one additional double bond on the side chain at carbon 24 (Stevenson and Brown, 2009). The conversion of desmosterol to cholesterol is mediated by 3-β-hydroxysterol delta-24-reductase (DHCR24), located in the endoplasmic reticulum (Peri et al., 2009).

    Desmosterol - an overview | ScienceDirect Topics

    sciencedirect.com
    What is desmosterol a sterol?
    J Alzheimers Dis. Author manuscript; available in PMC 2013 Jan 29. J Alzheimers Dis. 2013 Jan 1; 33 (3): 881–888. Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol.

    Alzheimer’s Disease: Brain Desmosterol Levels - PMC

    ncbi.nlm.nih.gov
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  10. ScienceDirect
    https://www.sciencedirect.com › topics › neuroscience › desmosterol

    Desmosterol - an overview | ScienceDirect Topics

  11. ScienceDirect
    https://www.sciencedirect.com › ... › desmosterol

    Desmosterol - an overview | ScienceDirect Topics

    Tags:
    Cholesterol
    Desmosterol
  12. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Regulated accumulation of desmosterol integrates macrophage …

    Tags:
    Publish Year:2012
    10.1016/j.cell.2012.06.054
    Published:2012/09/09
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