Dioxygenase - Wikipedia
Dioxygenases are oxidoreductase enzymes. Aerobic life, from simple single-celled bacteria species to complex eukaryotic organisms, has evolved to depend on the oxidizing power of dioxygen in various metabolic pathways.
Dioxygenase - an overview | ScienceDirect Topics
Dioxygenases are enzymes that incorporate both atoms of molecular oxygen into substrates, catalyzing reactions. They can be categorized as intramolecular dioxygenases, which use one substrate as the oxygen acceptor, or intermolecular dioxygenases, which act …
Dioxygenase enzymes: catalytic mechanisms and chemical models
Sep 1, 2003 · This review will describe the current understanding of the catalytic mechanism of a number of dioxygenase-catalysed reactions, and how in several cases this knowledge has been harnessed to design catalysts for biomimetic model chemistry. 1.1. Di-oxygenase and mono-oxygenase enzymes.
5.7: Oxygenases - Chemistry LibreTexts
The oxygenase enzymes catalyze reactions of dioxygen with organic substrates in which oxygen atoms from dioxygen are incorporated into the final oxidized product. 2-4 These enzymes can be divided into dioxygenases, which direct both atoms of oxygen into the product (Reaction 5.53), and monooxygenases, where one atom of oxygen from dioxygen is fo...
Dioxygenase - an overview | ScienceDirect Topics
Jan 14, 2011 · Dioxygenases are defined as enzymes catalyzing reactions in which both atoms of molecular oxygen are incorporated into substrates. In many instances where one substrate can act as the oxygen acceptor, the term ‘intramolecular dioxygenase’ may be used; pyrocatechase (catechol 1,2-dioxygenase) (EC 1.13.11.1) is a typical example.
Understanding human thiol dioxygenase enzymes: structure to …
Apr 24, 2017 · Metabolism of Cys is mainly regulated by two thiol dioxygenases: cysteine dioxygenase (CDO) and 2‐aminoethanethiol dioxygenase (ADO). CDO and ADO are the only human thiol dioxygenases reported with a role in Cys metabolism and localized to mitochondria.
Structure and Reaction Mechanism in the Heme Dioxygenases
Apr 4, 2011 · The heme dioxygenase enzymes catalyze the first and rate-limiting step in the kynurenine pathway, the O 2-dependent oxidation of l-tryptophan to N-formylkynurenine. This reaction is unique in heme chemistry.
Non-heme dioxygenases: cellular sensors and regulators jelly …
Feb 14, 2007 · Advances in Fe(II)/2-ketoglutarate-dependent dioxygenase-mediated C–H bond oxidation for regioselective and stereoselective hydroxyl amino acid synthesis: from structural insights into...
Catalytic Mechanisms of Fe (II)- and 2-Oxoglutarate-dependent ...
Aug 8, 2015 · The archetype hydroxylase is taurine:2OG dioxygenase (also known as taurine hydroxylase or TauD) that converts taurine (2-aminoethanesulfonic acid) to an intermediate that spontaneously decomposes to aminoacetaldehyde and sulfite (26, 27).
2-Oxoglutarate-dependent dioxygenases in cancer - Nature
Oct 21, 2020 · 2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many biological processes, including regulation of hypoxia-inducible factor-mediated...