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  1. Wikipedia
    https://en.wikipedia.org › wiki › ATP_citrate_synthase

    ATP citrate synthase - Wikipedia

    • ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of apparently identical subunits. In animals, the product, acetyl-CoA, is used in several important biosynthetic pathways, including lipogenesis and cholesterogenesis. It is activated by insulin. In plants, ATP citrate lyas… See more

    Overview

    ATP citrate synthase (also ATP citrate lyase (ACLY)) is an enzyme that in animals catalyzes an important step in See more

    Reaction

    ATP citrate lyase is responsible for catalyzing the conversion of citrate and Coenzyme A (CoA) to acetyl-CoA and oxaloacetate, driven by hydrolysis of ATP. In the presence of ATP and CoA, citrate lyase catal… See more

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    EC no.2.3.3.8
    CAS no.9027-95-6
    IntEnzIntEnz view
    BRENDABRENDA entry
    Location

    The enzyme is cytosolic in plants and animals. See more

    Structure

    The enzyme is composed of two subunits in green plants (including Chlorophyceae, Marchantimorpha, Bryopsida, Pinaceae, monocotyledons, and eudicots), species of fungi, glaucophytes, Chlamydomonas, and prokaryotes… See more

    Pharmacology

    The enzyme's action can be inhibited by the coenzyme A-conjugate of bempedoic acid, a compound which lowers LDL cholesterol in humans. The drug was approved by the Food and Drug Administration in … See more

    Further reading

    • Lovell SC, Davis IW, Arendall WB, de Bakker PI, Word JM, Prisant MG, et al. (February 2003). "Structure validation by Calpha geometry: phi,psi and Cbeta deviation". Proteins. 50 (3): 437–50. doi:10.1002/pr… See more

    External links

    • ATP Citrate Lyase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
    This article incorporates text from the United States National Library of Medicine, which is in the … See more

    Wikipedia text under CC-BY-SA license
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    Structure
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  1. ATP citrate lyase
    • According to 2 sources
    ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis.

    ATP-citrate lyase (ACLY) in li…

    pubmed.ncbi.nlm.nih.gov
    ATP citrate lyase (ACLY) is a cytosolic enzyme that converts mitochondrially derived citrate into acetyl-CoA and oxaloacetate, thereby defining the first step in the cellular fatty acid synthesis pathway; ATP is hydrolyzed concomitantly.

    ATP Citrate Lyase - an over…

    sciencedirect.com
  2. People also ask
    Does ACLY promote EC gluco-lipogenic metabolism?
    Increasing studies have revealed the role of ACLY in tumors and cardiovascular and fatty liver diseases [10, 16, 22, 35]. Here, we demonstrated that ACLY facilitated EC gluco-lipogenic metabolism by promoting MYC expression. This study recapitulated the regulatory role of ACLY in glycolysis and DNL.

    ATP-citrate lyase controls endothelial gluco-lipogenic ... - Nature

    nature.com
    How to lower my liver enzymes?

    Dr. Christa Kingston

    Doctor of Medicine (MD) · 9 years of exp

    Elevated liver enzymes imply damaged liver or inflamed liver. Liver enzymes can be lowered by stopping alcohol use, eating low protein diet, more of plant-based proteins can be taken instead of animal protein, decreasing the unnecessary use of pain medications and coffee intake.
    Q&A: Elevated Liver Enzymes
    bing.com
    Does ACLY acetylation regulate the enzymatic activity of NF- B?
    Moreover, acetylation-related ACLY nuclear translocation could promote the acetylation of NF- Îş B as well as its activity, leading to the proinflammatory response in macrophages, indicating the possible role of ACLY acetylation in regulating its enzymatic activity for producing acetyl-CoA .

    ATP-citrate lyase controls endothelial gluco-lipogenic ... - Nature

    nature.com
    Does ACLY promote cancer metastasis and fatty liver disease?
    It is well illustrated that ACLY participates in promoting cancer metastasis and fatty liver diseases. Its biological functions in ECs during sepsis remain unclear.

    ATP-citrate lyase controls endothelial gluco-lipogenic ... - Nature

    nature.com
    Are ACL enzymes homomeric?
    Animal ACL enzymes are homomeric; a fusion of the ACLA and ACLB genes probably occurred early in the evolutionary history of this kingdom. The mammalian ATP citrate lyase has a N-terminal citrate-binding domain that adopts a Rossmann fold, followed by a CoA binding domain and CoA-ligase domain and finally a C-terminal citrate synthase domain.

    ATP citrate synthase - Wikipedia

    en.wikipedia.org
    Does ACLY blockade improve EC proinflammatory response?
    ACLY inhibition significantly ameliorated lipopolysaccharide challenge-induced EC proinflammatory response in vitro and organ injury in vivo. The metabolomic analysis revealed that ACLY blockade fostered ECs a quiescent status by reducing the levels of glycolytic and lipogenic metabolites.

    ATP-citrate lyase controls endothelial gluco-lipogenic ... - Nature

    nature.com
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  3. Nature
    https://www.nature.com › articles

    Structure of ATP citrate lyase and the origin of citrate …

    Apr 3, 2019 · In autotrophic prokaryotes, ACLY is a hallmark enzyme of the reverse Krebs cycle (also known as the reductive tricarboxylic acid cycle), which fixates two molecules of carbon dioxide in...

    Tags:
    Citrate Lyase Enzyme
    ATP Citrate Synthase
    ATP Citrate Lyase Inhibitor Drug
  4. Neuroscience News
    https://neurosciencenews.com

    Key Enzyme Found to Drive Inflammation in Aging Cells

    Tags:
    Lyase
    Cell
  5. Nature
    https://www.nature.com › articles

    ATP-citrate lyase controls endothelial gluco-lipogenic ... - Nature

    Tags:
    ATP citrate lyase
    Ranran Li

  6. Images of enzyme ACLY

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  7. Nature
    https://www.nature.com › articles

    Molecular basis for acetyl-CoA production by ATP …

    Dec 23, 2019 · ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Accordingly, aberrant ACLY activity is observed in many diseases. Here we...

    Tags:
    ATP Citrate Lyase
    Publish Year:2019
    Acetyl Coa in Citric Acid Cycle
  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Exploring the Role of ATP-Citrate Lyase in the Immune System

    Tags:
    Lyase
    ACLY
  9. ScienceDirect
    https://www.sciencedirect.com › topics › biochemistry...

    ATP Citrate Lyase - an overview | ScienceDirect Topics

    Tags:
    ATP citrate lyase
    Citrate Lyase Enzyme
  10. ScienceDirect
    https://www.sciencedirect.com › topics › neuroscience › atp-citrate-lyase

    ATP Citrate Lyase - an overview | ScienceDirect Topics

    Tags:
    Citrate Lyase Enzyme
    ATP Citrate Synthase
    ATP Citrate Lyase Inhibitor Drug
  11. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    ATP citrate lyase (ACLY): a promising target for cancer ... - PubMed

    Tags:
    ATP citrate lyase
    Citrate Lyase Enzyme
    Lipid metabolism
    Publish Year:2015
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