Jan 1, 2014 · IL-3, IL-5, and GM-CSF are all encoded by closely linked genes on chromosome 5q31. Cell surface receptors for IL-3, IL-5, and GM-CSF receptors are detectable on immature multipotent eosinophil progenitor cells, eosinophil-committed precursors, as well …

Eosinophils originate from multipotent and lineage-restricted hematopoietic progenitor cells. Eosinophil progenitors reside in the bone marrow but are also detectable in the peripheral blood. Eosinophil development is regulated by eosinophilopoietic cytokines (IL-3, GM-CSF and IL-5) and takes place primarily in the bone marrow.

Eosinophil lineage–committed progenitors (EoPs) are phenotypically isolatable in the steady-state murine bone marrow. Purified granulocyte/monocyte progenitors (GMPs) gave rise to eosinophils as well as neutrophils and monocytes at the single cell level.

Eosinophil-lineage committed progenitor cells identified as CD45 + CD34 + IL-5Rα + cells by flow cytometry have been shown to be increased in the BM 24 h post-Ag challenge in mild asthmatics, with associated PB and sputum eosinophilia, and the development of AHR .

Jan 1, 2018 · Eosinophils differentiate in the bone marrow from an eosinophil lineage-committed progenitor (EoP) that is derived from the granulocyte/macrophage progenitor (GMP) in mice and the common myeloid progenitor (CMP) in humans.

Jan 16, 2009 · In mouse hematopoiesis, eosinophils originate from the eosinophil lineage-committed progenitor (EoP) that has been purified downstream of the granulocyte/macrophage progenitor (GMP). We show that the EoP is also isolatable in human adult bone marrow.

Mar 31, 2022 · This study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).

Feb 16, 2021 · A growing body of evidence shows that a balance between systemic differentiation and local tissue eosinophilopoietic processes driven by traffic and lung homing of bone marrow-derived hemopoietic progenitor cells (HPCs) are important components for the development of airway eosinophilia in asthma.

Apr 4, 2025 · Eosinophil-specific C5aR1 depletion did not affect the expansion of bone marrow mature eosinophils and EoPs or any of the investigated progenitor populations (Fig. 8D and fig. S11C). EoCre; C5ar1 fl/fl mice showed minor but significant expansion of bone marrow monocytes (PBS/HDME/HDME and SA/HDME/HDME groups) and neutrophils …

Jul 9, 2024 · We illustrate how these transcriptomic and immunophenotypic resources may be leveraged to investigate the molecular requirements and cellular dynamics of eosinophil progenitor maturation and expansion in eosinophilia and to elucidate how IL-5 depletion impacts eosinophil development.