Prevention and Treatment of Acneiform Rash Caused by EGFR …
May 15, 2013 · Treatment Recommendations. Prevention of acneiform rash caused by EGFR inhibitors includes topical corticosteroids (hydrocortisone 2.5%, alclometasone) and oral antibiotics (minocycline, doxycycline, or antibiotics covering skin flora) twice daily for …
In particular, a type of targeted treatment that blocks epidermal growth factor receptors (EGFRs) often causes rashes and other bothersome skin conditions. EGFRs are found in tumors, but they are also found normally in skin cells. (The word “epidermal” refers to skin.)
Management of Skin Toxicity Associated with Cetuximab Treatment …
Jan 27, 2011 · Topical treatment as for grade 2 can be used together with systemic therapy with oral semisynthetic tetracycline (minocycline, doxycicline) for ≥4 weeks and until the rash is asymptomatic, and oral corticosteroids (methylprednisolone 0.4 mg/kg, prednisone 0.5 mg/kg) for …
Epidermal Growth Factor Receptor Inhibitors and Skin Rash - U.S. Pharmacist
Jan 22, 2014 · Therapeutic intervention involves appropriate skin care, sun protection, moisturizers, topical corticosteroids, and topical or systemic antibiotics. Pharmacists can play an important role in the identification and appropriate treatment of EGFR inhibitor–related skin rash.
Skin lesions induced by cetuximab may predispose patients to superinfections (e.g. with S. aureus), which may lead to subsequent complications, e.g. cellulitis, erysipelas, or, potentially with fatal outcome, staphylococcal scalded skin syndrome or sepsis.
What are the recommended strategies for the prevention of rash associated with EGFR inhibitor therapy in adult patients with advanced non-small cell lung cancer, colorectal cancer, head and neck, or breast cancers?
EGFR Treatment for mCRC & SCCHN | ERBITUX (cetuximab)
Learn about starting treatment with ERBITUX, an EGFR inhibitor for metastatic colorectal cancer and head and neck cancer and possible side effects.
Outline of Procedure. This document covers the prevention and treatment of skin toxicity associated with systemic anti-cancer therapy in adult patients. Please refer to other appropriate guidelines for paediatric patients or skin toxicity related to other causes for example radiotherapy.
Incidence and management of cutaneous toxicities associated with cetuximab
The most commonly used agents are topical antibiotics, oral antibiotics, topical steroids, systemic immunomodulatory agents, topical immunomodulatory agents and anti-inflammatory preparations.
Head, Neck & Colorectal Cancer Treatment | ERBITUX (cetuximab)
Learn about ERBITUX, a treatment for metastatic colorectal cancer as well as certain types of head and neck cancers.