Germacrenes are a class of volatile organic hydrocarbons, specifically, sesquiterpenes. Germacrenes are typically produced in a number of plant species for their antimicrobial and insecticidal properties, though they also play a role as insect pheromones. Two prominent molecules are germacrene A and germacrene D. Germacrene has five isomers.

May 23, 2020 · Deprotonation of B leads to germacrene A, a widespread natural product and central intermediate in the biosynthesis of many 1,10-cyclised sesquiterpenes. This review discusses its occurrence in Nature, its chemistry, and central importance as an intermediate towards many sesquiterpenes.

Jan 7, 2021 · The sesquiterpene germacrene A is a direct precursor of ß-elemene that is a major component of the Chinese medicinal herb Curcuma wenyujin with prominent antitumor activity. The microbial platform for germacrene A production was previously established in Saccharomyces cerevisiae using the germacrene A synthase (LTC2) of Lactuca sativa.

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Germacrene A | C15H24 | CID 5835162 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Germacranes are important intermediates in the biosynthesis of eudesmane and guaiane sesquiterpenes. After their initial formation from farnesyl diphosphate, these neutral intermediates can become reprotonated for a second cyclisation to …

Sep 30, 2020 · This review summarises known sesquiterpenes whose biosyntheses proceed through the intermediate germacrene A. First, the occurrence and biosynthesis of germacrene A in Nature and its peculiar chemistry will be highlighted, followed by a discussion of 6-6 and 5-7 bicyclic compounds and their more com …

Nov 1, 2024 · This strategy involved (1) establishing a library of (+)-germacrene A synthase variants, (2) screening for highly efficient germacrene A synthases, (3) enhancing the catalytic efficiency of the chosen synthase, and (4) optimizing the …

Nov 14, 2022 · In this study, we sought to produce germacrene A in Escherichia coli through overexpression of GAS, introduction of the exogenous MVA pathway, fusion of enzymes, enhancement of the acetyl-CoA supply, and genomic insertion of the lower MVA pathway. Thereafter, the cobiosynthesis system for germacrene A and lycopene was explored.

Feb 26, 2025 · Germacrene A Synthase (LcTPS3) from Liriodendron was characterized. The biosynthesis of germacrene A was achieved in a yeast chassis, and the catalytic mechanism of LcTPS3 was further elucidated. Summary Plants produce a large array of natural products which play important roles in flavours, fragrances and medicines.