Anti-thymocyte globulin - Wikipedia
Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy …
Equine ATG as the First-Line Treatment for Aplastic Anemia
Aug 24, 2011 · ATG is an animal-derived product containing polyclonal antibodies, which are generated in either horse (Atgam, Lymphoglobulin, and Thymogam) or rabbit (Thymoglobulin) by inoculation with human thymocytes. Equine ATG has been used for the treatment of severe aplastic anemia since the 1980s.
Atgam® (Anti-thymocyte Globulin [Equine]) - OncoLink
Atgam® (Anti-thymocyte Globulin [Equine]) is used for some blood disorders, including aplastic anemia and Myelodysplastic Syndrome (MDS). It is also used to prevent the body from rejecting a kidney transplant, and in some cases, to prevent or treat Graft Versus Host Disease (GvHD).
How I treat acquired aplastic anemia | Blood | American Society of ...
Mar 16, 2017 · Horse ATG (ATGAM; Pfizer) has been compared with rabbit ATG (rATG) (Thymoglobulin; Sanofi France) in a prospective randomized trial and has been shown to be superior in terms of response at 6 months (68% vs 37%) and 3-year survival (96% vs 76%). 60 Similar results have been obtained in a matched-pair analysis of the EBMT 61 and in a ...
Optimal Dose Horse Antithymocyte Globulin for the Treatment of …
Dec 7, 2017 · Introduction: It is generally known that horse antithymocytic globulin (ATGAM) are more effective for treatment of pts with acquired AA than rabbit ATG. There is no doubt, that dose regime 160 mg/kg ATGAM Improves response for young pts after 1 st course.
Immunosuppressive Therapy | Aplastic Anemia and MDS …
ATG is created injecting human white blood cells (T cells) into a horse or a rabbit, and extracting the antibodies produced. A recent study conducted by the National Institutes of Health (NIH) found that horse-derived ATG provided a better overall response rate in aplastic anemia patients.
Horsies and Bunnies: Comparing Antithymocyte Globulin Drugs in …
In vivo T-cell depletion includes use of antithymocyte globulin (ATG), in the form of ATG-horse or ATG-rabbit agents, in combination with a calcineurin inhibitor and low-dose methotrexate to decrease the incidence of GVHD in patients undergoing HSCT.
How I treat acquired aplastic anemia | Blood - American Society …
Aug 9, 2012 · In patients who are not candidates for a matched related HSCT, immunosuppression with horse ATG plus cyclosporine should be the initial therapy. We assess for response at 3 and 6 months but usually wait 6 months before deciding on further interventions in case of nonresponders.
Jun 13, 2018 · In our experience, horse ATG as a first therapy for severe aplastic anemia has yielded a hematologic response rate of 60 to 65%,10-12 and we wished to improve this rate. We hypothesized that...
Horse versus rabbit antithymocyte globulin in ... - Springer
Sep 30, 2017 · ATG is a polyclonal antibody obtained from animals inoculated with human thymocytes or T cell lines. According to different genera, ATG is classified as horse and rabbit formulation. The best formulation in first-line IST remains unknown.