Jul 10, 2023 · The recommended initial dose of glucagon to reverse severe symptomatic beta-blockade is 50 mcg/kg IV as a loading dose, followed by an infusion of 1 to 15 mg per hour IV, titrated to clinical response and improvement.

Feb 17, 2020 · Intravenous labetalol is recommended for use in the management of acute onset, severe hypertension (systolic BP ≥160 mm Hg or diastolic BP ≥110 mm Hg) in pregnant and postpartum women. In general, avoid use of labetalol in women with asthma or heart failure (ACOG 202 2019; ACOG 767 2019; Magee 2014).

Usual dosage range: 200-400 mg PO q12hr; not to exceed 2400 mg/day. 20 mg IV over 2 minutes initially, then 40-80 mg IV q10min; total dose not to exceed 300 mg. Alternative: 1-2 mg/min...

Jun 4, 2024 · IV labetalol: IV Labetalol is a reasonable agent in most hypertensive emergencies, especially if you're trying to drop the Bp by only a moderate amount (e.g., 10-30 mm). For severe hypertension, IV labetalol is less effective than nicardipine.

Dec 29, 2016 · Labetalol is metabolized by the liver to form an inactive glucuronide conjugate. The hypotensive effect of labetalol begins within 2 to 5 min after its IV administration, reaching a peak at 5 to 15 min following administration, and lasting for about 2 to 4 h.

Jun 10, 2024 · Has been used for rapid reduction of BP in children and adolescents † [off-label] with acute severe hypertension † [off-label] and life-threatening symptoms. Has been used alone in patients with pheochromocytoma to control hypertension and symptoms resulting from excessive β-receptor stimulation.

Jan 18, 2025 · Time to onset of action: 5 minutes. Lowers blood pressure, reduces heart rate, myocardial oxygen consumption and myocardial contractility. Can be given as repeated intravenous bolus injections or as a constant-dose infusion. • 0.5–2 mg/minute IV infusion. Higher doses are sometimes required. Vomiting. Dizziness. Nausea.

Labetalol injection is used to treat severe high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.

In emergency care, labetalol is administered intravenously. Bronchodilator effects of beta-adrenergic agonists may be blunted bv labetalol. Nitroglycerin may augment hypotensive effects. Infusion: Mix 200 mg in 250 ml D5W (0.8 mg/ml); infuse at a rate of 2 mg/min, titrated to supine blood pressure. Safety has not been established.

Onset of action = 2-5min (IV) Duration of action = 2-4hr (IV) See Also. Beta-blockers; Beta-blocker toxicity; Antiarrhythmics; Antihypertensive medications; References. Labetalol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.