Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N 9 - glycosidic bond. It was discovered in 1965 in analysis of RNA transferase. [1] . Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs.

In this review, we summarize the latest progress in our understanding of the mechanistic function of inosine, to unravel its immunomodulatory actions in pathological settings such as cancer, infection, inflammation, and cardiovascular and neurological diseases.

Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N (9)-glycosidic bond. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines D-ribonucleoside and a member of inosines.

Inosinic acid or inosine monophosphate (IMP) is a nucleotide (that is, a nucleoside monophosphate). Widely used as a flavor enhancer, it is typically obtained from chicken byproducts or other meat industry waste. Inosinic acid is important in metabolism.

Inosin ist ein seltenes Nukleosid der RNA. Es besteht aus der β- D -Ribofuranose (Zucker) und dem Hypoxanthin, einer Base, die ein Purin als Grundgerüst hat, welches als Zwischenprodukt des Purinstoffwechsels entsteht. In der tRNA paart Inosin im Anticodon als Nukleotid in der Wobble-Position mit Cytidin, Uridin und Adenosin.

Jun 13, 2005 · Inosine is a nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose.

Inosine pranobex (IP), commonly known as inosine acedoben dimepranol, isoprinosine or methisoprinol, is a synthetic compound of the p-acetamido-benzoate salt of N–N dimethylamino-2-propanol with inosine in a 3:1 molar ratio, with immunomodulatory and antiviral properties.

Jun 15, 2020 · We demonstrate that the ribose subunit of inosine can enter into central metabolic pathways to provide ATP and biosynthetic precursors, and that cancer cells display diverse capacities to utilize...

Affiliations 1 Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Centre de Recherche des Cordeliers, Paris, France. Kroemer@orange.fr. 2 Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France. Kroemer@orange.fr. 3 Pôle de Biologie, Hôpital Européen Georges …

In addition, molecular inosine is an important secondary metabolite in purine metabolism that also acts as a molecular messenger in cell signaling pathways. Here, we review the functional roles of inosine in biology and their connections to human health. 1. Introduction.