Apr 3, 2003 · The agents we use most often are a mixture of these effects, with dopamine producing inotropic effects at lower doses and additional vasoconstrictor effects at higher doses.

Mar 19, 2002 · Left ventricular assist devices (LVADs) may be best used in patients with end-stage heart failure who are already on intravenous inotropic therapy, a subgroup analysis of the REMATCH trial shows.

Mar 10, 2011 · Inotropic therapy with dobutamine may also be necessary in myocardial dysfunction. Because hypotension may be life-threatening, vasopressors help to maintain adequate blood flow and tissue ...

Feb 26, 2025 · Five New Drugs in 4 Years “It’s a turning point in the history of treatment of HFpEF,” said Marco Metra, MD, director of the Institute of Cardiology at ASST Spedali Civili and professor at ...

Dobutamine is a synthetic catecholamine that has both inotropic and vasodilatory effects. Its mode of action is mediated via stimulation of both β 1 - and β 2 -adrenergic receptors.

Jan 6, 2004 · Response from Geoffrey Bihl, MD. Inotropes used intravenously for the treatment of hypotension are mostly very short-acting, their effects lasting from a few seconds to 1 or 2 minutes.

Mar 1, 2013 · Physiologic alterations in CHF, such as changes in absorption, distribution, metabolism, and elimination of drugs, can indeed alter loop diuretic pharmacokinetics; however, these effects do not ...

Mar 1, 2001 · Some inotropic drugs with a similar mechanism of action (phosphodiesterase inhibition) have been associated with increased mortality in patients with congestive heart failure (CHF).

Central nervous system effects of β-adrenergic-blocking drugs: the role of ancillary properties. Circulation 75(1), 204–212 (1987). Parker GW, Michael LH, Hartley CJ, Skinner JE, Entman ML.

Jan 30, 2025 · Read full-text medical journal articles from Medscape's Heart Failure: Cases & Quizzes.