Jun 7, 2023 · Thecal sac indentation occurs when external factors, such as a herniated disc or spinal stenosis, exert pressure on the sac, causing it to become compressed. This finding can be seen on MRI when being evaluated for back pain or other spinal conditions.

The thecal sac or dural sac is the membranous sheath (theca) or tube of dura mater that surrounds the spinal cord and the cauda equina. The thecal sac contains the cerebrospinal fluid which provides nutrients and buoyancy to the spinal cord. [1]

Intrathecal (IT) drug delivery systems (IDDS) are well-established as an effective therapeutic approach to patients with chronic non-malignant or malignant pain and as a tool for management of patients with severe spasticity and to deliver therapeutics that address a …

Intrathecal administration is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF). It is useful in several applications, such as for spinal anesthesia, chemotherapy, or pain management.

May 30, 2023 · The thecal sac is contained within the spinal canal, the bony channel that runs down the center of your vertebrae (the bones of your spine). Effacement of the thecal sac refers to a situation where the thecal sac is being compressed or “flattened” against the spinal cord.

Intrathecal (IT) administration, i.e., the injection of substances directly into the thecal sac that contains cerebrospinal fluid (CSF), is a potentially powerful drug delivery approach.

Jul 19, 2024 · Intrathecal therapy circumvents this obstacle by directly administering drugs into the CSF, enabling them to reach target sites such as the dorsal horn of the spinal cord without being impeded by the blood-brain barrier or undergoing first-pass metabolism.

Intrathecal (IT) injection is a promising alternative approach for bypassing the BBB and BSCB. By definition, IT injection refers to administration of a substance directly into the CSF that flows through the thecal sac.

May 15, 2017 · The intrathecal space is fluid filled and bounded by a nearly impermeable membranous sac. It nourishes, lubricates, and supports the spinal cord and the origination of the peripheral nervous system projections that emanate from the dorsal (sensory roots) and ventral (motor roots) horns.

Magnetic resonance imaging (MRI) demonstrated the presence of blood in the intrathecal space. This could be the cause of sacral radiculitis, an uncommon complication of an EBP. This suggests that EBPs could potentially cause neurologic symptoms which may be more common than people previously thought.