Sep 13, 2023 · Central to methimazole's mechanism of action is its potent inhibition of thyroperoxidase (TPO), an enzyme crucial for thyroid hormone synthesis. TPO catalyzes the iodination of tyrosine residues on thyroglobulin, leading to their subsequent coupling and the formation of T4 and T3.

Mechanism of action. Methimazole's primary mechanism of action appears to be interference in an early step in thyroid hormone synthesis involving thyroid peroxidase (TPO), however the exact method through which methimazole inhibits this step is unclear. 6 TPO, along with hydrogen peroxide, normally catalyzes the conversion of iodide to iodine ...

Aug 15, 2005 · Antithyroid drugs (methimazole [Tapazole] and PTU) Interferes with the organification of iodine; PTU can block peripheral conversion of T 4 toT 3 in large doses

Sep 13, 2023 · Methimazole exerts its therapeutic effect by inhibiting thyroperoxidase, a crucial enzyme in synthesizing thyroid hormones. This mechanism decreases the synthesis of thyroid hormones, specifically thyroxine (T4) and triiodothyronine (T3), restoring normal thyroid function.

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), and propylthiouracil (PTU) have extensively been used in the management of various forms of hyperthyroidism over the past eight decades. This review aims to summarize different aspects of …

Feb 17, 2020 · Includes Methimazole indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.

Antithyroid drugs are relatively simple molecules known as thionamides, which contain a sulfhydryl group and a thiourea moiety within a heterocyclic structure (Fig. 1). Propyl-thiouracil...

Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.

methimazole inhibits the thyroid enzyme thyroid peroxidase, also called iodide peroxidase, or thyroperoxidase (TPO). TPO performs two functions in thyroid hormone synthesis (Molina, 2018):

Mar 3, 2005 · Antithyroid drugs are associated with a variety of minor side effects, as well as potentially life-threatening or even lethal complications. 77–79 Side effects of methimazole are dose-related ...