Milrinone: Uses, Interactions, Mechanism of Action - DrugBank …
Milrinone is a PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population.
Milrinone - StatPearls - NCBI Bookshelf
Aug 28, 2020 · Milrinone is the phosphodiesterase inhibitor drug class. Phosphodiesterase is an enzyme that hydrolyzes the second messenger cyclic adenosine monophosphate(cAMP) and guanosine monophosphate(cGMP), terminating their effects in various tissues.
Milrinone - Wikipedia
Milrinone, sold under the brand name Primacor, is a pulmonary vasodilator [2] used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary vascular resistance.
Milrinone: Package Insert / Prescribing Info - Drugs.com
Dec 2, 2024 · Milrinone package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.
Milrinone • LITFL • CCC Pharmacology
Jul 13, 2024 · CLASS. bipyridine; MECHANISM OF ACTION. non receptor mediated inhibitor of cAMP phosphodiesterase III isoenzyme -> decrease the hydrolysis of cAMP; increase cAMP (analogous to activating a Gs protein)-> increase in adenyl cyclase-> increase protein kinases-> increased phosphorylation of proteins-> net influx of Ca2+ into muscle-> ‘inodilator’
Milrinone Uses, Side Effects & Warnings - Drugs.com
Apr 3, 2024 · What is milrinone? Milrinone is a vasodilator that is used as a short-term treatment for life-threatening heart failure. Milrinone may also be used for purposes not listed in this medication guide.
Milrinone Lactate Monograph for Professionals - Drugs.com
Jun 10, 2024 · Drug class: Cardiotonic Agents. Medically reviewed by Drugs.com on Jun 10, 2024. Written by ASHP. Positive inotropic agent that has vasodilating effects; a selective phosphodiesterase (PDE) inhibitor. Short-term management of acute …
Milrinone (Primacor) | Davis’s Drug Guide
Short-term treatment of HF unresponsive to conventional therapy with digoxin, diuretics, and vasodilators. Increases myocardial contractility. Decreases preload and afterload by a direct dilating effect on vascular smooth muscle. Therapeutic Effect (s): Increased cardiac output (inotropic effect).
Milrinone | C12H9N3O | CID 4197 - PubChem
Milrinone is a member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.
Milrinone - Deranged Physiology
Milrinone. Class: Ino-dilator Chemistry: Biperidine. Routes of administration: IV; but can also be administed as a nebulised aerosol, and had initially been marked as an oral preparation. Absorption: Well absorbed orally; 92% oral bioavailability. Solubility: pKa 4.6 and 8.5; good solublity at physiological pH. Distribution
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