Multidrug-resistant (MDR) bacteria are bacteria that are resistant to three or more classes of antimicrobial drugs. [1] MDR bacteria have seen an increase in prevalence in recent years [clarification needed] [2] and pose serious risks to public health. MDR bacteria can be broken into 3 main categories: Gram-positive, Gram-negative, and other ...

May 17, 2024 · The World Health Organization (WHO) today released its updated Bacterial Priority Pathogens List (BPPL) 2024, featuring 15 families of antibiotic-resistant bacteria grouped into critical, high and medium categories for prioritization.

Nov 21, 2023 · Multidrug-resistant tuberculosis (MDR-TB) is a form of TB caused by bacteria that do not respond to isoniazid and rifampicin, the two most effective first-line TB drugs. MDR-TB is treatable and curable by using second-line drugs, but these medicines are expensive and toxic, and in some cases more extensive drug resistance can develop.

Many different bacteria now exhibit multi-drug resistance, including staphylococci, enterococci, gonococci, streptococci, salmonella, as well as numerous other Gram-negative bacteria and Mycobacterium tuberculosis.

Apr 12, 2024 · This guideline provides recommendations for management of multidrug-resistant organisms in healthcare settings.

In some residential settings (e.g., LTCFs), it is important to control multidrug-resistant S. pneumoniae (MDRSP) that are resistant to penicillin and other broad-spectrum agents such as macrolides and fluroquinolones (18, 19).

When a bacterium is resistant to at least one antibiotic in three (or more) different antibiotic classes it is said to be multidrug-resistant. This can happen in two separate ways. A bacterium can have several different resistance genes, each providing resistance to a particular antibiotic.

The emergence of multidrug-resistant organisms in both community- and hospital-acquired infections is resulting in increased morbidity, mortality, and healthcare expense. The growing threat of antimicrobial resistance calls for a new approach.

From a clinical perspective, our greatest concerns are multidrug-resistant microbes (MDRs) and cross resistance. MDRs are colloquially known as “superbugs” and carry one or more resistance mechanism (s), making them resistant to multiple antimicrobials.

Mar 12, 2025 · The escalating global health crisis of antibiotic resistance, driven by the rapid emergence of multidrug-resistant (MDR) bacterial pathogens, necessitates urgent and innovative countermeasures.