The Evolution of Multimeric Protein Assemblages - PMC
Drawing from these observations, an attempt is made below to identify the population-genetic conditions that most plausibly promote the emergence of multimeric protein assemblages.
8: Protein Structure, Self assembly – Multimeric Proteins, …
Multimeric proteins/quaternary structure - assembly of multiple subunits into a functional protein (Image Source: https://en.wikipedia.org/wiki/ATP_sy...p_synthase.PNG, …
AF2Complex predicts direct physical interactions in multimeric …
Apr 1, 2022 · Here, we demonstrate that the same neural network models from AF2 developed for single protein sequences can be adapted to predict the structures of multimeric protein …
Designed protein multimerization and polymerization for ...
Jan 27, 2022 · Multimeric proteins are commonly prepared by genetic modification, whereas polymeric proteins are usually created through PTMs. There are two methods that can be …
Quaternary Structure and Function of Multimeric Proteins
Multimeric proteins play crucial roles in cellular processes, impacting everything from enzyme activity to structural integrity. These complex assemblies, composed of multiple protein …
Split GFP technologies to structurally characterize and quantify ...
Oct 25, 2017 · Protein multimerization in physiological and pathological conditions constitutes an intrinsic trait of proteins related to neurodegeneration.
A hydrophobic ratchet entrenches molecular complexes - Nature
Dec 9, 2020 · To understand why multimeric interfaces persist and change over evolutionary time, we studied the evolution of steroid receptors (SRs), a protein family in which dimerization has …
Evolutionary diversification of the multimeric states of proteins
Jul 7, 2013 · To explain these observations, a model is presented for the stochastic origin of variation in the multimeric states of proteins via the joint processes of mutation, random …
Multimeric Proteins that Can Come Apart, Change Shape, and …
Apr 20, 2020 · Herein we describe progress in a class of shape-shifting proteins originally called morpheeins. These are homomultimers that can dissociate, change conformation in the …
Protein complex - Wikipedia
A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multidomain enzymes, in which multiple catalytic …