Mustafa Ahmed was born in Toronto, Ontario to Sudanese parents.

Mustafa performed an original piece, "A Single Rose", at Nelson Mandela Park Public School. The piece attracted praise at Hot Docs Canadian International Documentary Festival.

Mustafa published "Rabba" with the Toronto-based artist collective Halal Gang.

Mustafa co-wrote the song "Attention" by The Weeknd on the latter's album Starboy.

Mustafa was featured on the Now's list of Toronto musicians to watch for in 2017.

Mustafa performed at the Fast in the 6 festival at Nathan Phillips Square held on 1 June 2018. He paid condolences to his deceased associate, Smoke Dawg, who had been gunned down on 30 June 2018, in front of a Toronto nightclub.

Mustafa co-wrote the Jonas Brothers single "Sucker". He released Remember Me, Toronto, a short Canadian documentary film about the hip hop culture in Canada in 17 March 2019. A line from his poem "From the Perspective of Black Love" was featured as part of the Valentino's autumn/winter 2019 collection. His collaborations would be worn by Emilia Clarke at a Game of Thrones premiere.

Mustafa released his debut single "Stay Alive". The single prompted Complex to list Mustafa on the list of Best New Artists of the March 2020.

Mustafa released his debut album When Smoke Rises on 28 May 2021. The album won the 2022 Juno Award for Alternative Album of the Year and was shortlisted for the 2021 Polaris Music Prize. Numerous publications named Mustafa as an 'artist on the rise.

Mustafa lost his older brother Mohamed Ahmed as the victim of a daytime shooting.