001976 NOD/ShiLtJ The NOD/ShiLtJ strain (commonly called NOD) is a polygenic model for autoimmune type 1 diabetes. Diabetes in NOD mice is characterized by hyperglycemia and insulitis, a leukocytic infiltration of the pancreatic islets.

We focus here on the unmanipulated NOD mouse and discuss features of the husbandry and investigation of the mice that allow for use of these long-studied mice in the pathogenesis of an autoimmune type of diabetes.

Non-obese diabetic (NOD) mice exhibit a susceptibility to spontaneous development of autoimmune insulin dependent diabetes mellitus (IDDM). [6] The NOD strain and related strains were developed at Shionogi Research Laboratories in Aburahi, Japan by Makino and colleagues and first reported in 1980. [ 7 ]

In NOD mice, type 1 diabetes development is well-choreographed when all the relevant environmental factors (pathogen status, diet and so on) are held constant.

In this study, NOD mice genetically deficient in MyD88, an adaptor protein for multiple Toll-like receptors, were found to be resistant to diabetes development and to exhibit altered gut flora. Strikingly, transfer of this altered flora rendered germ-free NOD mice resistant to Type 1 diabetes.

When combined with various versions of the severe immunodeficient NOD mice (e.g., NSG mice), expression of HLA class I or II molecules in the absence of murine counterparts provides a superior host for primary human T cells and hematopoietic stem cell-derived immune system .

NOD mice may have abnormalities in IFN-gamma production. (Tsumura et al 1989). Newborn pinealectomy accelerates the development of diabetes in females while exogenous melatonin protects the mice though it results in an increase in insulin …

The nonobese diabetic (NOD) mice originated in the 1980s when researchers in Japan were trying to develop a strain of mice prone to cataract, but instead the mice spontaneously developed diabetes at a young age similar to juvenile diabetes in humans, more commonly referred to as type 1 diabetes (T1D) 1. It is now established that, like in human ...

Immunodeficient NOD mice advance both diabetes and human infectious disease research. Two distinct research goals drove the development of NOD immunodeficient models: 1) The development of a mouse that could be used to uncover which immune cells actually drive the development of autoimmune diabetes in NOD mice.

Apr 29, 2022 · Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the pathophysiology of this disease shares many similarities with human type 1...