Nucleoside analogues are structural analogues of a nucleoside, which normally contain a nucleobase and a sugar. Nucleotide analogues are analogues of a nucleotide , which normally has one to three phosphates linked to a nucleoside.

May 1, 2020 · The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella-zoster (VZV) infection.

Nucleoside analogs play a crucial role in the production of high-value antitumor and antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid degradation, chemical synthesis, and biotransformation.

Dec 1, 2022 · Nucleoside analogues are the fundamental agents in which several drugs are available against cancer and bacterial antibacterial (Thomson et al., 2019). Nucleotide and nucleoside analogues are significant antiviral agents inhibiting polymerases and …

Oct 27, 2008 · Nucleoside analogs are structurally similar antimetabolites that have a broad range of action and are clinically active in both solid tumors and hematological malignancies.

May 1, 2020 · The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella-zoster (VZV) infection.

Nucleoside analogs, structurally modified nucleosides, typically undergo phosphorylation to their triphosphate form within cells. They are classified as competitive inhibitors, competing with natural substrates for binding to the viral polymerase.

Oct 12, 2023 · Nucleoside analogs play a crucial role in the production of high-value antitumor and antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid degradation, chemical synthesis, and biotransformation.

Feb 20, 2014 · Many azanucleosides are potent antiviral, anticancer and antimicrobial agents, or serve as valuable components of oligonucleotides with improved stability, binding or hybridization properties. Therefore, the development of new analogues is a very active area in medicinal and synthetic chemistry.

A nucleoside analogue is a pharmacological compound with properties such as cytotoxic, immunosuppressive, and antiviral effects. These compounds, derived from modified purine and pyrimidine nucleobases, are effective in cancer treatment and interact with DNA to induce structural changes.