Ofatumumab - Wikipedia
Ofatumumab is a fully human monoclonal antibody to CD20, which appears to provide rapid B-cell depletion. [13] Under the brand name Kesimpta , it is approved for the treatment of multiple sclerosis in the United States as well as in the European Union and other regions.
Ofatumumab: Uses, Dosage, Side Effects, Warnings - Drugs.com
Nov 25, 2024 · Ofatumumab (brand names Kesimpta and Arzerra) is a monoclonal antibody that is approved to treat multiple sclerosis (MS) under the brand name Kesimpta and chronic lymphocytic leukemia (CLL) under the brand name Arzerra.
Ofatumumab - Cleveland Clinic
A: Ofatumumab is a fully-humanized monoclonal anti-CD20 antibody constructed with recombinant DNA techniques and designed to selectively target CD20-expressing B-cells. Following cell surface binding, ofatumumab selectively depletes CD20-expressing B-cells through antibody-dependent cellular phagocytosis, antibody-dependent cellular ...
Ofatumumab (intravenous route, subcutaneous route) - Mayo …
Ofatumumab can temporarily lower the number of white blood cells in your blood, increasing the chance of getting a serious infection (eg, bacterial, fungal, viral). It can also lower the number of platelets, which are necessary for proper blood clotting.
Kesimpta: Uses, Dosage, Side Effects, Warnings - Drugs.com
Dec 9, 2024 · Kesimpta (ofatumumab) is an FDA-approved medicine used to slow the progression and risk of relapses for specific forms of relapsing multiple sclerosis (MS). It is a once-a-month injection given under the skin (subcutaneously) that you can self-administer in your own home.
The Development of Ofatumumab, a Fully Human Anti-CD20 …
Ofatumumab is the first fully human anti-CD20 monoclonal antibody to be approved for the treatment of relapsing multiple sclerosis. Rapid and sustained near-complete B-cell depletion can be achieved with ofatumumab treatment and maintained …
Ofatumumab: A Review in Relapsing Forms of Multiple Sclerosis
Ofatumumab (Kesimpta ®) is a fully human anti-CD20 monoclonal antibody that can be self-administered by patients and is approved in several countries worldwide for the treatment of relapsing forms of multiple sclerosis (MS).
Ofatumumab Injection (Multiple Sclerosis) - MedlinePlus
Ofatumumab injection is used to prevent episodes of symptoms and slow the worsening of disability in adults who have relapsing forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control ...
Ofatumumab: Uses, Interactions, Mechanism of Action
Mar 19, 2008 · Ofatumumab is an anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications. Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells.
Ofatumumab - PMC
Ofatumumab is an anti-CD20 IgG1κ human monoclonal antibody that is being considered by the US Food and Drug Administration and the European Medicines Agency for marketing approval as a treatment for chronic lymphocytic leukemia.